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iloperidone improves levels of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Iloperidone is often a time-dependent CYP3A inhibitor and should bring about amplified plasma levels of medicine predominantly eliminated by CYP3A4.fedratinib will increase the level or effect of ethinylestradiol by affecti